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Gut microbes produce trimethylamine (TMA) moieties from common dietary precursors, such as choline or carnitine, which are subsequently metabolized by the liver into TMAO

More recent systematic reviews and meta-analyses published between 2020 and 2022 have broadly confirmed this picture, reporting small, short-term reductions in body weight and body mass index, particularly in older adults and individuals with obesity or metabolic conditions, but with effect sizes that remain clinically modest

Astrocytes in stress accumulate lipid droplets

Macrophage plasticity, polarization, and function in health and disease

Metab Brain Dis

Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S et al (2010) Iodine intake as a determinant of thyroid disorders in populations