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8.1.4 Research limitations and considerations While the evidence is compelling, several limitations must be acknowledged, including the reliance on observational studies for human data, potential confounding factors in epidemiological investigations, and the extrapolation challenges from animal models to human populations

FIGURE 3 4 Robust synergistic therapy against cancer 4.1 Sensitized chemotherapy As a chemotherapeutic agent, platinum is one of the most widely used metal-based anticancer components ( via increasing drug solubility (Rabik and Dolan, 2007)

Activation of the NRF2 pathway, including induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), promotes autophagic clearance and restrains over-activation [87] (Fig