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Deferoxamine (DFO), an FDA-approved iron chelator, effectively inhibits ferroptosis by binding free Fe 3 , decreasing ROS production, and upregulating ferroptosis-protective proteins such as GPX4, ferritin heavy chain 1 (FTH1), and system x [30]

Rezk NA, Zidan HE, Riad M, Mansy W, Mohamad SA

Dumay J, Moranais M

L., Siwak, E

The depletion of GPX4 and GSH, the increased level of lipid peroxidation, and disrupted iron metabolism are vital features of ferroptosis ( Being a novel mode of cell death, ferroptosis is known to be related to tumor progression and therapeutic efficacy

doi: 10.1016/j.fsi.2023.108696 121 HuangQ.ShamR