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Limitations This article is not based on a systematic review, but here, we complemented our recent systematic review on melatonin supplementation [84] with a comprehensive review that included recent research findings, a clinician-researcher view, and evidence for melatonin dysregulation in specific psychiatric disorders

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PEGylation reduces their clearance rate in the blood, prolongs circulation time, and reduces non-specific adsorption ( in vitro and reducing FA-induced A assembly