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DErrico F, Goverse G, Dai Y, Wu W, Stakenborg M, Labeeuw E, De Simone V, Verstockt B, Gomez-Pinilla PJ, Warner M, Di Leo A, Matteoli G, Gustafsson JA
The meeF-meeY (FY) mutant strain can be rescued by induction of the expression of FtsH, an ATP-dependent metalloprotease that is known to clear jammed SecYEG translocons (Figure 58, left )
EGF-receptor inhibition may prevent tumor cell dissemination
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Key findings: Used daily Used continuously Used for months , not weeks Demonstrated safety without tolerance development No cycling protocols were included
