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Early pathogenic events are characterized by synaptic dysfunction and mitochondrial impairment, which are strongly linked to increased reactive oxygen species (ROS) levels, disrupted intracellular Ca 2+ homeostasis, and decreased adenosine triphosphate (ATP) production 83

CB-839, a small-molecule GLS-1 inhibitor, decreases GLS-1 activity and inhibits CLL cell proliferation

Both topical and oral administration led to a favorable modulation of the inflammatory response, with a significant reduction in acne lesions reported among participants after cream application (409)

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Sample handling strategies for the determination of biophenols in food and plants