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They could be identified as a dihydropyranone adduct containing one molecule glutathione and a ketohexanoic acid bearing two glutathione molecules

Macromol 309, 142635

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Subsequent phase I clinical trials demonstrated a strong synergistic effect of lenvatinib in combination with the EGFR inhibitor gefitinib in advanced HCC with high expression of EGFR and refractory to lenvatinib mono-therapy, with 9 out of 30 cases achieving partial response (NCT04642547)

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(PubMed) US Department of Health and Human Services, National Institutes of Health, Office of Dietary Supplements
