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Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

While some individuals may notice improvements in general well-being within a few weeks, more significant liver-specific benefits, such as enhanced detoxification or cellular regeneration, typically require consistent use over several months

Some of the clinical trials are investigating combination therapies by including CAR-T with chemotherapy or with checkpoint inhibitors (immunotherapy)

Mechanistically, oxidative stress has been identified as a key factor in nicotine dependence
