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glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ERα in breast Unveiling the Role of Glutathione

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2017 Apr 14;6(4):e005790

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

Oncogene 40(35):54165426 Liu L et al (2024) Acyltransferase zinc finger DHHC-type containing 2 aggravates gastric carcinoma growth by targeting Nrf2 signaling: A mechanism-based multicombination bionic nano-drug therapy

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

Further, glutamate can be converted into glutamine, which is considered the main substitute of glucose (134)

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

Conversely, H3K27me3 is often removed during ROS accumulation, enabling derepression of antioxidant-related genes [44]

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

Due to its potential interactions with chemotherapy agents, caution is advised when used in patients undergoing cancer treatments

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

Where indicated, reactions included 20 U/mL superoxide dismutase and/or 30 U/mL catalase

glutathione and breat cancer cells Glutathione-responsive PROTAC for targeted degradation of ER in breast Unveiling the Role of Glutathione

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