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Normalized bigWig files, scaled to 1 million mapped reads, were generated using BEDTools

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Results Identification of SARS-CoV-2 3CL protease inhibitors from DNA-encoded chemical library screening Aiming to screen 2.8 billion compounds in a DNA-encoded chemical library (DELopen by WuXi AppTec) for SARS-CoV-2 3CL protease inhibitors, we captured His-tagged 3CL protease on Ni-NTA magnetic beads for binding affinity screening (Supplementary Fig