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This data corroborates our in vitro analysis, since as we have shown, higher amount of NRF2 and GSH mediate tumor resistance to cisplatin treatment, ultimately leading to a worse prognosis for lung cancer patients

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Therefore, LA may be used as a liver-protective substance in hepatic fatty accumulation caused by MCD, but it needs to be used with caution

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Vaporciyan A, Wang XS, Bashkar S, Correa A, Qiuling S, Gning I, Hofstetter W, Rice D, Mehran R, Swisher S, Cleeland C

Interestingly, in renal clear cell carcinoma, IDO expressed by neovascularization endothelial cells is an inhibitory factor in tumor growth because it limits the flow of tryptophan from the blood to the tumor or produces tumor toxic substances (Riesenberg et al., 2007)