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Description
Various cationic polymers, including polyethylenimine (PEI), polyamidoamine dendrimers (PAMAM), poly-L-lysine (PLL), poly--aminoester (PBAE), and poly-lactic-co-glycolic acid (PLGA), have been developed for this purpose (Fig
The activated PARPase utilizes NAD + as a substrate to transfer ADP-ribose units one by one to the target protein, forming poly ADP-ribose chains

These findings suggest that curcumin exerts its antitumor effects in colon cancer at least in part by suppressing miR-130a, thereby downregulating Wnt/-catenin signaling and inhibiting tumor cell proliferation (31)

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