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In still further embodiments, a formulation or composition disclosed herein is applied at or near the round window membrane via a microinjection device
Moreover, copper dyshomeostasis can promptly lead to neurological disease
PND35-60) and fresh solution was prepared every 2 days
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While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)
[DOI] [PubMed] [Google Scholar] 184.Li N., Shi F., Wang X., Yang P., Sun K., Zhang L., Hao X., Li X., Li J., Jin Y
