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These agents inhibit di- and tetrahydrofolate reductase activity in humans resulting in a disruption of one carbon metabolism 60,61

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J Lab Clin Med 1967;70:15869

If those mutations occur in a gene important to cancer prevention, then a tumor can occur.[ref] Thus, folate helps to prevent the mutations that cause cancer, yet in someone who has cancer, folate and methyl groups can fuel cancer cell growth