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Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))

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Consecutive injections of low doses of TAM let all four substances accumulate, but they were efficiently excreted within 7 dpi, similar to a recent study, where different doses of TAM (up to 400 mg/kg body weight within 24 h) were compared 24

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