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In vivo studies have demonstrated that quercetin lowers blood pressure and improves endothelial function in spontaneously hypertensive rats (SHR) by activating eNOS and suppressing NADPH oxidase [105]

10.3389/fneur.2018.00640 42 KontosH

1 Introduction CKD, which is defined by the gradual loss of kidney function and progressive structural damage, has become a pressing public health concern globally, including in China

For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]

ChemBioChem 21 , 113119 (2020)

V., Zellner, A