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Although GPX4 is unique from the other GPX enzymes in that it is not limited to GSH and may use other thiol-containing proteins as reductants as well

Acute sleep deprivation appears to be associated with a physiological stress/metabolic response of higher cortisol levels, especially at night, whereas chronic circadian misalignment appears to result in a physiological adaptation that reduces 24-h cortisol levels with associated increases in pro- and anti- inflammatory proteins

Kamakura, JP

This results in decreased activity of HIF1, a transcriptional factor critical for maintaining astrocyte glycolytic capacity, thereby impairing lactate production

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Yegneswaran B., Kostis J.B., Pitchumoni C.S

The findings indicate that abemaciclib, in combination with RT, enhanced tumor cell radiosensitivity, enhanced gamma-H2AX phosphorylation, reduced AKT phosphorylation, attenuated PI3K/mTOR signaling, alleviated radiation-induced vasculogenesis, and enhanced tumor growth delay (Naz et al