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Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

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Specifically, GLP-1 RAs showed significantly reduced risks of progression to systolic heart failure (HR 0.60) and stroke (HR 0.75) compared to SGLT2 inhibitors

Eating less often means consuming less protein, which can affect lean muscle maintenance