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Under non-treated conditions, I/R is reflected by morphological alteration, reduction of -glutamyl transpeptidase (-GGT) activity, and increased cell apoptosis

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Additionally, its favorable safety profile, with adverse event rates comparable to vehicle in clinical trials, supports its suitability for long-term management of CHE compared with traditional topical therapies [108]

However, detailed results from these trials have not been published in peer-reviewed journals, limiting comprehensive assessment of clinical efficacy

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