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J Biol Chem 289(11):78357843

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However, randomized trials in relatively healthy older adults demonstrate limited overall clinical benefit, with subgroup analyses suggesting that responsiveness may vary according to sex, age strata, and baseline physiological reserve

Therefore, the efficacy of tamoxifen, potentially derived from endoxifen, can be undermined by the use of co-administered SSRIs (Stearns et al ., 2003

1 In recent years, with the widespread use of immune checkpoint inhibitors (ICIs), a new type of DILI has been observed that requires unconventional approaches to treatment