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High-performance multi-dynamic bond cross-linked hydrogel with spatiotemporal siRNA delivery for gene-cell combination therapy of intervertebral disc degeneration

It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis

Zwitterions are crucial for the overall structure and function of proteins as they play a vital role in stabilizing the three-dimensional structure through various interactions like hydrogen bonding and electrostatic interactions

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achieving a key approach to increase effective lipophilicity, reduce hydrogen bonding with water and decrease hydrodynamic radius, thereby enhancing epithelial absorption, solubility and permeability, reinforcing the therapeutic potential of intramolecular hydrogen bonding [85]

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