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Plant 12 , 704714 (2019) Kang, J.H., Shi, F., Jones, A.D., Marks, M.D., Howe, G.A.: Distortion of trichome morphology by the hairless mutation of tomato affects leaf surface chemistry

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[27] From cobalt-sirohydrochlorin to cobalt-factor III [edit] As in the aerobic pathway, the third methyl group is introduced by a methyltransferase enzyme, CbiL: [26] cobalt-sirohydrochlorin + S-adenosyl methionine cobalt-factor III + S-adenosyl-L-homocysteine From cobalt-factor III to cobalt-precorrin-4 [edit] Methylation and ring contraction to form the corrin macrocycle occurs next, catalysed by the enzyme Cobalt-factor III methyltransferase (CbiH, EC 2.1.1.272) [28] cobalt-factor III + S-adenosyl methionine cobalt-precorrin-4 + S-adenosyl-L-homocysteine In this pathway, the resulting material contains a -lactone, a six-membered ring, rather than the -lactone (five-membered ring) of precorrin-3B

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