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However, lasers should be used with caution in melasma treatment, especially in darker skin tones, because it can often worsen melasma and hyperpigmentation
Cell Metab (2008) 8:23748

Glove-related contact dermatitis: diagnostic value of a repeated application test

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This makes it a pleiotropic regulator , a molecule that modulates many processes, all of which are important for regeneration and slowing of ageing

(PubMed) Namazi N, Larijani B, Azadbakht L
