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In short: while the studies suggest a vaguely positive trend, the design lacks rigour, and the conclusions are highly speculative

Despite its dominant role, it is increasingly recognized that excessive reliance on FAO may contribute to disease progression in HF

At low concentrations of Asc (less than 20 mmol/L), chloroplast APX activity is rapidly decreased in the presence of H 2 O 2 , with an inactivation half-life of the 30 s

[DOI] [PMC free article] [PubMed] [Google Scholar] Firsov D, and Bonny O (2018)

doi: 10.1016/j.ccell.2018.08.007

Toxicity was size- and dose-dependent and regulated by insulin signaling pathways [143]