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A 2015 paper in Nature Scientific Reports identified that gut microbiota actually convert berberine into dihydroberberine (DHB) in the intestinal wall, and it's the DHB that gets absorbed and then converts back to berberine in the bloodstream

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6C, Additional file 2: Data S1)

PMID: 33416981 Biochem JSOX2 knockdown slows cholangiocarcinoma progression through inhibition of transcriptional activation of lncRNA PVT1

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