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Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis

10.1038/sj.jid.5700701 42 EmmersonS.MukherjeeS.Melendez-MunozJ.CousinsF.EdwardsS

Kidney-selective prodrugs of 6-mercaptopurine: biochemical basis of the kidney selectivity of S -(6-purinyl)-L-cysteine and metabolism of new analogs in rats

Southern Thoracic Surgical Association Annual Meeting 2025, 2025

Under physiological conditions, more than 98% of the total GSH pool exists in the reduced form, thereby shaping cellular redox potential and influencing proliferation, differentiation, and cell death 5 .Although the GSH/GSSG ratio has long been regarded as an indicator of cellular redox status, recent live-cell studies using genetically encoded redox sensors indicate that increases in GSSG are typically transient and compartmentalized rather than sustained intracellular accumulations 6,7

Early studies showed that it works as a selective GH secretagogue and that it has a short, well-characterized half-life