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One of the main functions of vitamin C is its role as a cofactor of enzymes such as -ketoglutarate and iron-dependent dioxygenases (Fe 2+ /-KGDDs), where it partially maintains the reduced state of the Fe 2+ ion ( in vivo (Table 1)

Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation (Conesa et al., 2023)

Reyes-Gordillo, K

Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)

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