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Consistent with this role, when ceruloplasmin is lacking in astrocytes, neurons increase HEPH expression to maintain iron efflux, preventing intracellular iron build-up [87]

Suggested Use: Take 1 capsule with 12 to 16 ounces of water one to three times daily, or as recommended by your healthcare professional

This work was supported by National Institutes of Health grants 2R01AI077562 and R01GM139215 (S.T.), National Science Foundation Graduate Research Fellowship DGE 16-44869 (S.B.B.), and National Institutes of Health grant 1K99AI153530 (W.J.)

Open-field test The open-field test was used for evaluation of anxiety and locomotion