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Gastroenterology 131 , 11531163 (2006)

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While they are normally the result of stress, free radicals can be caused by other environmental factors like smoke and pollutants

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Supplementing with riboflavin altered the DNA methylation in people with MTHFR C677T, causing a decrease in methylation of the ACE gene.[ref] Benefits of supplemental riboflavin: Clinical trial data Clinical trials are an excellent way to know if a supplement is effective for most people