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Genes Associated with Mitochondrial Dysfunction in Parkinsons Disease The first PD-associated gene, synuclein alpha ( SNCA ), was discovered in 1997 (Polymeropoulos et al., 1997)

doi: 10.1016/j.autrev.2012.02.013 508 KleinRBergP

2 There is no proof in large prospective, double-blind studies that oral supplementation is as effective in reducing symptoms associated with vitamin B12 deficiency as parenteral treatment

5.1.3 Retinoids All trans retinoic acid (ATRA), isotretinoin, retinol, retinaldehyde, tazarotene, and adapalene are among retinoids used as depigmenting agents in melasma management

Serum half-life for a healthy individual taking a therapeutic dose ranges from 1.5 to 3 h

Everett, S