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Single doses in the range of 3 to 6 grams were less likely to provoke symptoms, but larger doses, especially when taken in a single serving, often resulted in diarrhea and other gastrointestinal symptoms

421,527 Amitriptyline is the most frequently prescribed TCA and is relatively inexpensive

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2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults