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Although a possible neurotransmitter role was claimed, i.e., for prostaglandins [144,145,146,147] and somatostatin [148,149,150], this was not combined with the cytoprotective effect and possible pleiotropic effect (organoprotection)

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This highlights the necessity for collaboration between colorectal surgeons and gastroenterologists to optimize surgical planning, manage complex cases, and prevent complications

Dose Escalation Strategy The single most effective strategy for minimizing side effects is following the recommended gradual dose escalation protocol

doi: 10.1111/j.1365-2265.2009.03667.x 49 DelgrangeERaverotGBexMBurmanPDecoudierBDevuystFet al