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Additionally, a persons risk increases to a 1 in 22 chance if they have a first-degree relative with celiac disease and a 1 in 39 chance if they have a second-degree relative (Fasano, 2002)

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Therefore, heterozygous carriers do not require treatment

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Therefore, the primary candidate for FRDA clinical translation became deferiprone (DFP), a small, lipophilic bidentate chelator capable of crossing cellular and mitochondrial membranes to access and theoretically redistribute the toxic accumulation of mitochondrial iron to extracellular sinks [117,118]

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Depletion of Arg1-positive microglia/macrophages exacerbates cerebral ischemic damage by facilitating the inflammatory response

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