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Numerous studies have indicated that oxidative stress is important in the development of atherosclerosis (Marchio et al., 2019

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Ding K, Song F, Sun W, Sun M, Xia R

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Furthermore, in the gastrocnemius muscle of SOD1 G93A mice, the activities of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH) were found to be reduced in the late symptomatic phases of the disease, indicating impairments in the TCA cycle pathway (Tefera et al., 2016)

Of interest, insulins ability to inhibit hepatic acetyl CoA and lipolysis is lost in high-fat-fed rats, a phenomenon reversible by IL-6 neutralization and inducible by IL-6 infusion (80)

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