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Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

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Sequential transitions with an adequate washout period are established methodology, unlike concurrent stacking

Although the reactivity of compound was only about 15times higher than that of ebselen under indentical condition, the catalytic mechansium involves the formation of an unusual spiro compound [47]