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The recommended doses for this group are peginterferon alpha-2b, 1 g/kg subcutaneously once weekly or peginterferon alfa-2a, 135 g subcutaneously once weekly, together with ribavirin, 200 to 800 mg per day in 2 divided doses, starting with the low dose and increasing gradually as long as side effects are minimal and manageable

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Ornithine and urea generated by the arginase pathway can serve as carbon and nitrogen sources for other gut microbial species (Lu, 2006)