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Preclinical and small-scale clinical studies suggest potential benefits of NRF2 activation, high-dose thiamine, CoQ10, molecular hydrogen, and oxygen-ozone (O 2 O 3 ) therapy

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Safety, Efficacy Evidence, and Who Should Consider Supplementation Glutathione is generally recognized as safe at supplemental doses (up to 1000 mg daily), though long-term efficacy studies remain limited

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Rapamycin therapy also preserved the function of ACSL4 overexpression in increasing cell proliferation and preventing cell death (109)