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Within mammalian cells, numerous kinases are expressed in G1-phase mitotic cells, including the complexes Cdk4/cyclin-D, Cdk6/cyclin-D, Cdk2/cyclin-E, Cdk2/cyclin A, and Cdk1/cyclin A, which play key roles in progressing the cells from phase G1 to phase S

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Chemotherapy can induce senescence (Ewald et al., 2010), and we therefore determined whether therapeutic removal of senescence could influence chemotoxicity

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These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation

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