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To overcome these translational barriers and navigate the narrow therapeutic window, future clinical strategies must pivot towards precision medicine, focusing on: (1) Patient Stratification and Personalized Therapy: Utilizing iron-sensitive MRI techniques like QSM and CSF iron-related biomarkers for patient stratification to enable personalized, tailored, and adjustable chelation regimens that maximize net benefit and minimize the risk of excessive iron removal [123, 133]

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Nanoparticle diffusion in respiratory mucus from humans without lung disease