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Mechanism of Action: Octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors Dopamine beta-hydroxylase converts tyramine to octopamine Octopamine can be taken up into storage vesicles in nerve terminals, and then be released by nerve stimulation Octopamine exerts only a small effect on postsynaptic receptors compared to norepinephrine (hence the designation false transmitter) Notes: Octopamine typically exists in only trace amounts in the mammalian CNS, but accumulates when MAO is inhibited (e.g

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At the same time, glutamate can be released from astrocytes 78 through several mechanisms including exocytosis 53,79 , Sxc cystine/glutamate antiporter 80 or diffusion through plasmalemmal channels, such as Bestrophin-1 (Best-1) anion channels or two-pore-domain potassium channel TREK-1 81