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Gwyer, D., Wragg, N
Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain
doi: 10.1007/BF01210408
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A plot of enzymatic rate as percentage of the total reaction rate against pH showed the contribution by the true enzyme

Risks from Unregulated Use Quality Concerns : Without FDA regulation, quality can vary