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Notably, ANGII-induced left ventricular hypertrophy and remodeling occurred both in the presence ( 2.1.2 Aldosterone and salt infusion after unilateral nephrectomy (H 2 FPEF score 2) Initially described in rats, the combination of aldosterone infusion, unilateral nephrectomy and 1% sodium chloride (NaCl) loading induces blood pressure elevation, concentric LV hypertrophy with diastolic dysfunction and pulmonary congestion in both C57BL/6 and FB/N mice (Tanaka et al., 2016

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Los mecanismos directos promueven el catabolismo de las hemoprotenas y derivados, mientras que los indirectos disminuyen el estrs oxidativo derivado de la presencia de estas molculas, eliminando las especies reactivas de oxgeno o reparando los posibles daos ocasionados (fig

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