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For Use in Horses Only: Recommended to support a normal balance of intestinal microflora by supporting growth of beneficial bacteria in the gut, in addition to supporting normal health of intestinal tissue & a healthy immune system

10.1016/j.phrs.2022.106141 43

The most common clinical presentation consists of lethargy, jaundice, nausea, vomiting, haemorrhage, worsening seizures and anorexia [23]

The pathophysiology is characterised by a negative protein and energy balance driven by a variable combination of reduced food intake and abnormal metabolism (Fearon et al., 2011)

However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]

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