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Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis

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26 Hypoxia not only activates NF-B signalling to trigger peritubular inflammation but also activates Wnt and Notch-1 signalling to promote fibrosis

The cholinergic anti-inflammatory pathway, mediated by acetylcholine release via the vagus nerve, is another potential therapeutic target[84]