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While traditional paradigms have centered on erythropoietin deficiency and iron dysregulation, it is now evident that accelerated erythrocyte deathdriven by uremic toxins, oxidative stress, chronic inflammation, and iron imbalanceplays a critical role in reducing red blood cell lifespan and exacerbating anemia

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They modulate immune cell functions and inflammatory responses via multiple pathways, thereby influencing pathogen clearance and lung tissue repair

doi: 10.1038/s41581-022-00633-5 82 DaiHLanPZhaoDAbou-DayaKLiuWChenWet al

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