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The growing interest in novel antifungal mechanisms, such as focusing on vital genes or cellular processes, blocking virulence factors, preventing stress-reaction signaling, using compound combinations, and creating immunomodulatory treatments, gives potential therapeutic options

The formulations efficacy is based on dextromethorphans effect on neurotransmission, which can mitigate excitotoxic effects, coupled with quinidines ability to enhance dextromethorphans cerebral presence by inhibiting efflux transporter activity (49)

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The free sale or self-administration of such substances for the purpose of biohacking is therefore illegal

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