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Extraction solvent must be selected based on extraction methods, especially, SFE- and enzyme-assisted extractions combining co-solvent like hexane and acetone is advantageous for combined non-polar and polar effects ( Various extraction procedures have been used to obtain phytochemicals, and can be classified as conventional- (e.g., hydrodistillation, steam distillation and Soxhlet extraction) and advance extraction methods (e.g., enzyme- assisted-, instant controlled pressure drop-, microwave- assisted-, pressurized liquid-, solar energy- based-, sub- critical-, supercritical fluid-, and ultrasound-assisted extractions) (Table 1 compares the conventional and advance extraction techniques in terms of extraction time, solvents consumption, instrumentation cost, sample size, and extraction yield and quality

doi: 10.36849/jdd.6197

Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: a randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers