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For instance, demented APOE4 carriers display decreased levels of several lipid classes, such as phosphatidylethanolamine (PE) and phosphatidic acid (PA) [139]

Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

All participants were men with confirmed diagnoses of localized non-metastatic adenocarcinoma of the prostate who were scheduled to receive external-beam radiation therapy

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Neurology 83 , 12771284 (2014)

& Bartfai, T