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They include genetic, neurogenic, autoimmune, oxidative stress and other theories

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Interestingly, lactate-dependent histone lactylation at H4K12la enriched at the promoters of glycolytic genes have been found in microglia adjacent to A plaques in brain samples from mouse models of Alzheimers disease and individuals with Alzheimers disease 122

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[DOI] [PMC free article] [PubMed] [Google Scholar] Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J