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Eur J Heart Fail 2007

But when the same receptor gets hit with the same signal nonstop, a chain of events unfolds: The cell marks the receptor with a chemical tag (phosphorylation) A protein called beta-arrestin grabs the tagged receptor and shuts down further signaling The cell pulls the receptor inside (internalization) Some receptors get recycled and put back on the surface

Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation

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Then, BA are further converted to the major secondary BA metabolized by the gut microbes [8, 9]

Currently, the Phase III program is focused on this genetically high-risk group, but future expansion is planned to include individuals with one copy of the APOE4 gene (heterozygotes) and even noncarriers